Studies on Pyrimidine Derivatives and Related Compounds. XLV. On Some Synthetic Methods of N-[1-(2-Oxo-1,3-oxathian-4-ylidene) ethyl]-N-[(2-methyl-4-amino-5-pyrimidinyl)-methyl] formamide
スポンサーリンク
概要
- 論文の詳細を見る
The reaction of phosgene with thiamine chloride (IIa) or nitrate (IIb) gave O-chlorocar-bonylthiamine (IX) in good yield. Treatment of IX with alkali afforded N-[1-(2-oxo-1,3-oxathian-4-ylidene) ethyl]-N-[(2-methyl-4-amino-5-pyrimidinyl) methyl] formamide (XIII). The reaction of thiamine sodium salt (III) with aryloxycarbonyl chloride (phenoxy-, p-methyl-phenoxy, p-methoxyphenoxy) gave corresponding S-aryloxycarbonylthiamine (XIIa〜c), and further treatment of XIIa〜c with alkali afforded XIII in good yield. On the other hand, IX reacted with sodium salts of phenol, p-cresol, and p-methoxyphenol to give corresponding O-aryloxycarbonylthiamine (XIa〜c). Treatment of XIa〜c with alkali also gave XIII in low yield. Therefore, it was assumed that XI and XII gave XIII in independent way by alkali treatment.
- 公益社団法人日本薬学会の論文
- 1967-06-25
著者
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平井 健太郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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伊藤 寿子
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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浜島 好男
Shionogi Research Laboratory Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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