Studies on the Pyrimidine Derivatives. XXII. The Syntheses of New Thiamine Derivatives.

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概要

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• Direct introduction of substituents of organic groups to the hydroxyl group of thiamine was achieved by the use of phosgene. O-Chlorocarbonylthiamine (VI) thus prepared was converted into O-carbamoylthiamine and O-alkoxycarbonylthiamine. The free bases of O-carbamoyl derivatives were assigned dihydrothiochrome structures (XV) and (XVI). S-Carbamoylthiamine derivatives were also prepared. Application of S→O rearrangement of the carbamoyl group gave various O, S-bis substituted thiamine derivatives.

• 公益社団法人日本薬学会の論文
• 1963-07-25

著者

• 平井 健太郎

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 浜島 好男

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 高見沢 映

  Shionogi Research Laboratory Shionogi & Co. Ltd.

関連論文

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