On the Reaction of Dialkyl Acylphosphonate with 2-Methylthiazolium Salts
スポンサーリンク
概要
- 論文の詳細を見る
Dialkyl acylphosphonate worked as an acylating agent on 2-methylthiazolium and thiazolinium salts in the presence of base, to give 2-acylidenethiazoline and thiazolidine derivatives, respectively. Dialkyl [1-aryl (alkyl)-1-dialkylphosphatomethyl] phosphonate was also isolated as a by-product in the same reaction. Dialkyl acylphosphonate afforded 2-acylidenethiazolines in better yield compared with acyl chlorides and showed on apparent affinity for carbanions. Application of diethyl benzoylphosphonate to 1,2,3-trimethylbenzimidazolium iodide, however, formed a dimeric salt, 1,1', 3,3'-tetramethyl-2,2'-(2-phenyltrimethylene) di (benzimidazolium) diiodide in addition to 2-(1,3-dimethylbenzimidazolin-2-ylidene) acetophenone. On the basis of the reactivity difference between the 2-methylthiazolium and 2-methylimidazolium salts and the kinetic experiments, the mechanism of the acylating reaction was proposed.
- 公益社団法人日本薬学会の論文
- 1977-05-25
著者
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高見沢 映
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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原田 紘
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
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松下 至博
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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松下 至博
Shionogi Research Laboratories Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
-
原田 紘
Shionogi Research Laboratory Shionogi And Co. Ltd.
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原田 紘
Shionogi Research Laboratories Shionogi & Co. Ltd.
関連論文
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