Optical Resolution and Chiral Synthesis of Methyl 6,7-Dichloro-2,3-dihydrobenzo[b]furan-2-carboxylate

概要

論文の詳細を見る
Optical isomers of methyl 6,7-dichloro-2,3-dihydrobenzo[b]furan-2-carboxylate (2) were prepared by means of both optical resolution and chiral synthesis. The resolution of the carboxylic acid 3 was achieved in a practical and efficient way via the l-and d-menthyl esters, which were directly converted to enantiomers of 2. Chiral synthesis of 2 was attained with high optical yield via acidcatalyzed cyclization of the β-hydroxysulfide 10 derived from optically active glycidyl phenyl sulfide 13. The optical resolution method was considered to be better for large-scale preparation from the economical and operational viewpoints.
公益社団法人日本薬学会の論文
1988-03-25