Studies on Pyrimidine Derivatives and Related Compounds. LXXXVII. Reaction of Thiamine Analogues with Diethyl Benzoylphosphonate
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概要
- 論文の詳細を見る
Reaction of thiamine analogues lacking the 5-hydroxyethyl group (6a-e) with diethyl benzoylphosphonate (7) was carried out. Comparison of reactivity in 4'-substituted thiamine analogues and those lacking the hydroxyethyl group suggests the presence of an interaction in the thiamine molecule between the pyrimidine ring and the hydroxyethyl group in an aprotic solvent. Reactivity at the 2 position (the active center in enzymatic decarboxylation) in 4'-substituted thiamine analogues may be affected by this interaction.
- 公益社団法人日本薬学会の論文
- 1974-12-25
著者
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高見沢 映
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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原田 紘
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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原田 紘
Shionogi Research Laboratory Shionogi And Co. Ltd.
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原田 紘
Shionogi Research Laboratories Shionogi & Co. Ltd.
関連論文
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