Studies on Pyrimidine Derivatives and Related Compounds. LIX. Syntheses of 2,3-Dihydro-1H-pyrazolo [5,1-b] purin-2-ones
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概要
- 論文の詳細を見る
Syntheses of 2,3-dihydro-1H-pyrazolo [5,1-b] purin-2-ones (Va-c) from 7-amino-pyrazolo [1,5-a] pyrimidin-6-carbohydrazides (IVa-c) involving a ring formation were described. Acid hydrolysis of Va-b gave 6,7-diaminopyrazolo [1,5-a] pyrimidines (VIa, b). Both VIa and VIb reproduced Va and Vb by the reaction with phosgene respectively. Hydrolytic decomposition of Vb under more vigorous condition afforded 6-amino-7-oxo-4,7-dihydropyrazolo [1,5-a] pyrimidine (VIII), which was identified with the compound synthesized by another method. In Va-c remarkable hypocholesteric activity and enhancement effect of lypolitic activity on ACTH were observed.
- 公益社団法人日本薬学会の論文
- 1968-11-25
著者
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高見沢 映
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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浜島 好男
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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林 貞男
Shionogi Research Laboratory Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
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酒井 昇二
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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浜島 好男
Shionogi Research Laboratory Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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酒井 昇二
Shionogi Research Laboratory Shionogi And Co. Ltd.
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酒井 昇二
Shionogi Research Laboratory Shionogi & Co. Ltd.
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林 貞男
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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