Studies on Pyrimidine Derivatives and Related Compounds. L. Reactions of Thiamine with Aldehydes
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of thiamine-sodium salt (IV) with benzaldehyde in the presence of carbon dioxide afforded 2-benzoyl-3-(2-methyl-4-aminopyrimidin-5-yl-methyl)-3a-methylperhydrofuro [2,3-d] thiazole (Va) involving an unusual carbon-acylation at thiazole C-2 position of thiamine, and stereochemistry of the product was discussed. Va was also obtained from reaction of thiamine hydrochloride (I) with benzaldehyde in the presence of triethylamine under anhydrous condition. Some other aldehydes also reacted to furnish corresponding C-2 acylated thiamine derivatives.
- 公益社団法人日本薬学会の論文
- 1968-07-25
著者
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平井 健太郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
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浜島 好男
Shionogi Research Laboratory Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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松本 佐市
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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石破 暉之
Shionogi Research Laboratory Shionogi & Co. Ltd.
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松本 佐市
Shionogi Research Laboratory Shionogi And Co. Ltd.
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