Interaction of Peptido-aminobenzophenones with Benzodiazepine Receptors
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概要
- 論文の詳細を見る
Peptido-aminobenzophenones exhibit potent central nervous system activities similar to those of benzodiazepines in experimental animals, despite their lack of the diazepine skeleton. These compounds have low affinity for benzodiazepine receptors, but are converted into compound (s) having high affinity for the receptors by incubation with crude synaptosomes from rat brains or rat liver homogenates. This conversicn seems to involve an enzymatic process, because it is temperature-dependent and stereospecific. The results suggest that peptido-aminobenzophenones show their pharmacological activities through conversion into benzodiazepine (s) in vivo.
- 社団法人日本薬学会の論文
- 1980-05-25
著者
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平井 健太郎
塩野義製薬研究所
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藤本 正文
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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平井 健太郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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藤本 正文
Shionogi Research Laboratories Shionogi & Co. Ltd.
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月野木 祐二
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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岡林 直
Shionogi Research Laboratories Shionogi And Co. Ltd.
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元瀬 勝己
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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元瀬 勝己
Shionogi Research Laboratory Shionogi And Co. Ltd.
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月野木 祐二
塩野義製薬研究所
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月野木 祐二
Shionogi Research Laboratory Shionogi And Co. Ltd.
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