Studies on the Pyrimidine Derivatives. XXX. Syntheses and Reactions of O-(2-Tetrahydropyranyl)-thiamine, O-Tritylthiamine, S-Acylthiamine, and S-Alkoxycarbonylthiamine.
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概要
- 論文の詳細を見る
O-(2-Tetrahydropyranyl) thiamine (II) and O-tritylthiamine (III) were prepared from O-(2-tetrahydropyranyl) SB_1 (V) and O-trityl SB_1 (VII), respectively. II and III were converted into S-alkoxycarbonyl or S-acyl derivatives, and removal of the trityl group gave S-acylthiamine. S-Alkoxycarbonyl and S-acylthiamine reacted with phosgene to give O-chlorocarbonyl derivatives, which were converted into O-alkoxycarbonyl-and O-carbamoylthiamine. These compounds were also obtained from S-alkoxycarbonyl-and S-carbamoylthiamine by S→O rearrangement. The combination of these reactions gave various kinds of thiol type thiamine derivatives.
- 公益社団法人日本薬学会の論文
- 1964-05-25
著者
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平井 健太郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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浜島 好男
Shionogi Research Laboratory Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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畠 町子
Shionogi Research Laboratory Shionogi & Co. Ltd.
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