On the Reactions of Oxazolium Salts with Dialkyl Acylphosphonates. A Novel Synthesis of 1,4-Oxazin-3-one and Azetidin-2-one Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of Oxazolium salts (IX) with dialkyl acylphosphonates (IV) in the presence of triethylamine afforded 1,4-oxazin-3-one (XII) and/or azetidin-2-one derivatives (XIII). In the reaction of IXa-b with IVa, stable reaction intermediates (Xa-b) were isolated. Some of the products were confirmed to be identical with authentic samples synthesized by an independent pathway. The mechanism of this novel reaction involving ring expansion and ring contraction, substituent effects on the reactivity, and stereochemistry of XIII are discussed.
- 公益社団法人日本薬学会の論文
- 1974-07-25
著者
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高見沢 映
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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佐藤 久夫
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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佐藤 久夫
塩野義製薬株式会社研究所
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佐藤 久夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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