Studies on Pyrimidine Derivatives and Related Compounds. XLVI. The Reactions of Diethyl Acetylphosphonate with Thiamine : Takamizawa Reaction (5).

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概要

• 論文の詳細を見る

• 3-(2-Hydroxy-and 2-acetoxy) ethyl-1,4,9-trimethyl-1,6-dihydropyrimido [4', 5'-4,5] pyrimido-[2,3-c] [1,4] thiazine (IIIb and IVb) were obtained by the reaction of thiamine (I) and diethyl acetylphosphonate (IIb). Alkaline hydrolysis of IIIb or IVb gave 2-methyl-4-(2-methyl-4-amino-5-pyrimidinyl)-methyl-5-methyl-6-(2-hydroxy) ethyl-2H-1,4-thiazin-3 (4H)-one (Vb), which was decomposed to give VIIb by conc. HCl. The structures of IVb and VIIb were confirmed by the synthetic method.

• 社団法人日本薬学会の論文
• 1967-08-25

著者

• 佐藤 義朗

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 高見沢 映

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 佐藤 久夫

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 浜島 好男

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 佐藤 久夫

  塩野義製薬株式会社研究所

• 佐藤 久夫

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 浜島 好男

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 高見沢 映

  Shionogi Research Laboratory Shionogi & Co. Ltd.

関連論文

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