Studies on Pyrimidine Derivatives and Related Compounds. LIV. Reactions of Thiamine with α-Ketoaldehydes

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概要

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• Reaction of thiamine-sodium salt (III) with phenylglyoxal in the presence of carbon dioxide yielded 2-phenyloxalylthiamine (Va) which underwent facile air oxidation to thiamine thiazolone (VI) and phenylglyoxylic acid. Thiamine hydrochloride (I) was also condensed with phenylglyoxal in the presence of triethylamine or sodium hydroxide to give Va. The reaction was applied to a number of α-ketoaldehydes including some heterocyclic glyoxals to give corresponding 2-oxalylthiamine derivatives (Vb-1) which were shown to be convertible into stable acyl derivatives (XIa-r).

• 公益社団法人日本薬学会の論文
• 1969-01-25

著者

• 高見沢 映

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 高見沢 映

  新潟薬科大学

• 酒井 昇二

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 高見沢 映

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 酒井 昇二

  Shionogi Research Laboratory Shionogi And Co. Ltd.

• 酒井 昇二

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 松本 佐市

  Shionogi Research Laboratory, Shionogi and Co., Ltd.

• 松本 佐市

  Shionogi Research Laboratory Shionogi And Co. Ltd.

関連論文

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