Oxidation of α-Ketoaldehyde by Thiamine and Hydride Acceptor:A Chemical Model for a New Role of Thiamine in the α-Ketoaldehyde Metabolism
スポンサーリンク
概要
- 論文の詳細を見る
An adduct of phenylglyoxal with thiamine was readily converted to phenylglyoxylate and thiamine by the action of organic hydride acceptors such as 2, 6-dichlorophenol indophenol, trityl cation, 2-methyl-3-benzylidene-indolenium salt and N-methylnicotinamide. Similar hydride transfer reaction was observed for the adduct of methylglyoxal with thiamine. Direct conversion of phenylglyoxal to phenylglyoxylate by 2, 6-dichlorophenol indophenol was found to occur in the presence of TPP and base. The results indicate a new catalytic role for thiamine in the conversion of α-ketoaldehyde to α-ketoacid.
- 日本ビタミン学会の論文
著者
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牧野 逸男
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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高見 沢映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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松本 佐市
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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松本 佐市
Shionogi Research Laboratory Shionogi And Co. Ltd.
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牧野 逸男
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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高見 沢映
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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