Studies on Pyrimidine Derivatives and Related Compounds. LX. Synthesis of Hydroxymethylthiamine

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概要

• 論文の詳細を見る

• Hydroxymethylthiamine, phosphate free "active formaldehyde, " was synthesized by the acid treatment of 2-phenyloxalylthiamine-O, O'-diacetate or 2-α-furyloxalylthiamine-O, O'-diacetate, and on alkaline treatment it was converted into a dimeric 1,4-oxazine derivative (X) involving a ring expansion and auto-oxidation.

• 公益社団法人日本薬学会の論文
• 1969-02-25

著者

• 高見沢 映

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 高見沢 映

  新潟薬科大学

• 酒井 昇二

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 高見沢 映

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 酒井 昇二

  Shionogi Research Laboratory Shionogi And Co. Ltd.

• 酒井 昇二

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 松本 佐市

  Shionogi Research Laboratory, Shionogi and Co., Ltd.

• 松本 佐市

  Shionogi Research Laboratory Shionogi And Co. Ltd.

関連論文

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• Studies on Pyrimidine Derivatives and Related Compounds. XLVII. Reaction of Thiamine with Dialkyl Acylphos-phonates or Methyl Phenylacyl-phosphinates : Takamizawa Reaction 6
• Studies on Pyrimidine Derivatives and Related Compounds. XLVI. The Reactions of Diethyl Acetylphosphonate with Thiamine : Takamizawa Reaction (5).
• Studies on the Pyrimidine Derivatives and Related Compounds. XL. Reaction of 3-Benzyl-4-methyl-5-(2-hydroxyethyl)thiazolium Salts with Diethyl Benzoylphosphonate
• Studies on the Pyrimidine Derivatives and Related Compounds. XXXIX. On the Oxidation Products of 2-Pheny1-4-(2-methyl-4-amino-5-pyrimidyl)methyl-5-methyl-6-(2-benzoyloxy or hydroxy)-ethyl-4H-1,4-thiazin-3(2H)-one
• 14.ビタミンB_1関連チアゾール誘導体とDiethylbenzoylphosphonateとの反応(第155回会議研究発表要旨)
• Studies on the Pyrimidine Derivatives. XXVII. A New Method for Synthesis of Diethyl Ethoxycarbonylphosphite from Tris (ethoxythiocarbonyl) Phosphorotrithioite, and on the Reactions of these Organo-phosphorus Compounds with Thiamine Sodium Salt.
• Studies on Pyrimidine Derivatives and Related Compounds. LIII. The Reaction of Thiamine with Diethyl Acetylphosphonate (Supplement) and the Synthesis of Pseudothiamine
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