An Unusual Heterocyclic Transformation in Liquid Ammonia
スポンサーリンク
概要
- 論文の詳細を見る
By the action of liquid ammonia, the cyclpadducts of isothiocyanates with 3,4-dimethyl-5-(2-hydroxy) ethylthiazolium ylides (Ia-b) are converted into spiro [3,3a-dimethylperhydrofuro [2,3-d] thiazole-2,4'-(5'-iminoimidazolidine)] derivatives (IIa-b), while the reactions of liquid ammonia with N-benzyl analogues (Ic-e) afford 3-aryl-6,8-dimethyl-2,9-dithia-4,6,8-triazatricyclo [3,3,0,1^<1,5>] oct-3-enes (IIIa-c) involving an unusual base-catalyzed cleavage reaction of the fused spiro thiazolidine ring. A possible mechanism of the novel transformation reaction is suggested.
- 公益社団法人日本薬学会の論文
- 1973-06-25
著者
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高見沢 映
新潟薬科大学
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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松本 佐市
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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松本 佐市
Shionogi Research Laboratory Shionogi And Co. Ltd.
関連論文
- Studies on Pyrimidine Derivatives and Related Compounds. LXXV. Reactions of Thiazolium Salts with Diethyl Acylphosphonates and Hydroxylation of Some 3-Oxo-2,3-dihydro-4H-1,4-thiazine Derivatives
- Studies on Pyrimidine Derivatives and Related Compounds. XLVII. Reaction of Thiamine with Dialkyl Acylphos-phonates or Methyl Phenylacyl-phosphinates : Takamizawa Reaction 6
- Studies on Pyrimidine Derivatives and Related Compounds. XLVI. The Reactions of Diethyl Acetylphosphonate with Thiamine : Takamizawa Reaction (5).
- Studies on the Pyrimidine Derivatives and Related Compounds. XL. Reaction of 3-Benzyl-4-methyl-5-(2-hydroxyethyl)thiazolium Salts with Diethyl Benzoylphosphonate
- Studies on the Pyrimidine Derivatives and Related Compounds. XXXIX. On the Oxidation Products of 2-Pheny1-4-(2-methyl-4-amino-5-pyrimidyl)methyl-5-methyl-6-(2-benzoyloxy or hydroxy)-ethyl-4H-1,4-thiazin-3(2H)-one
- 14.ビタミンB_1関連チアゾール誘導体とDiethylbenzoylphosphonateとの反応(第155回会議研究発表要旨)
- Studies on the Pyrimidine Derivatives. XXVII. A New Method for Synthesis of Diethyl Ethoxycarbonylphosphite from Tris (ethoxythiocarbonyl) Phosphorotrithioite, and on the Reactions of these Organo-phosphorus Compounds with Thiamine Sodium Salt.
- Studies on Pyrimidine Derivatives and Related Compounds. LIII. The Reaction of Thiamine with Diethyl Acetylphosphonate (Supplement) and the Synthesis of Pseudothiamine
- Studies on Pyrimidine Derivatives and Related Compounds. LII. Reaction of Thiamine with Phosphites. (1)
- Studies on the Pyrimidine Derivatives and Related Compounds. XXXV. On the Reaction Product of Thiamine with Diethyl Benzoylphosphonate
- ピリミジン誘導体および関連化合物の研究 : (LV)ビタミンB_1-モノグルタミン酸塩の合成と安定性
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- On the Reaction of Dialkyl Acylphosphonate with 2-Methylthiazolium Salts
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- Studies on Pyrimidine Derivatives and Related Compounds. LXX. A Novel Reaction of Thiamine Anhydride
- Studies on Pyrimidine Derivatives and Related Compounds. LXIX. Sythesis of Thiamine Free Base
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