Studies on Pyrimidine Derivatives and Related Compounds. LXV. On the Reactions of Thiamine with Carbon Disulfide
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概要
- 論文の詳細を見る
The action of CS_2 on B_1-HCl in MeOH after treatment with Et_3N gave B_1-methyl-xanthogenate (II). This reaction was applied to potassium xanthogenate as a new B_1 precipitant. The reaction of II with primary amines gave thioureas, while the reaction with secondary amines yielded corresponding 2-methyl-4-amino-5-pyrimidinylmethylcarbodithioates by exchange with thiazole moiety of B_1. This substitution reaction was found to be caused by the reaction between B_1 and aminocarbodithioate. On the other hand, the reaction of CS_2 with B_1-Na salt followed by the action of alkyl halides afforded the S-dithioalkoxycarbonylthiamines readily.
- 公益社団法人日本薬学会の論文
- 1969-11-25
著者
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平井 健太郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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石破 暉之
塩野義製薬(株)研
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石破 暉之
Shionogi Research Laboratory Shionogi & Co. Ltd.
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