Studies on Pyrimidine Derivatives and Related Compounds. LXVII. Reaction of Thiadiazolium Derivatives with Dialkyl Acylphosphonates
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概要
- 論文の詳細を見る
Reaction of 1,2,4-thiadiazolium salts with dialkyl acylphosphonates (II) afforded ring expanded products, 1,2,4-thiadiazine derivatives. In the reaction of 4-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-methyl-1,2,4-thiadiazolium bromide hydrobromide (VII) with dialkyl benzoylphosphonates (IIb, c), however, 10a (1-dialkylphosphoroyl) benzyl-4,5,10,10a-tetrahydro-3,8-dimethyl-1,2,4-thiadiazolo [4', 5'-1,2] pyrimido [4,5-d] pyrimidine (VIIIb, c) were obtained as major products and the 1,2,4-thiadiazine derivative (IX) as a minor product. Acid treatment of VIIIb, c gave XIb, c, which were intermediates of the reaction of the thiadiazolium salt (VII) with phosphonate (IIb, c), and these were converted to VIIIb, c and IX by alkaline hydrolysis.
- 公益社団法人日本薬学会の論文
- 1970-07-25
著者
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高見沢 映
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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原田 紘
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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原田 紘
Shionogi Research Laboratory Shionogi And Co. Ltd.
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原田 紘
Shionogi Research Laboratories Shionogi & Co. Ltd.
関連論文
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