Studies on Pyrimidine Derivatives and Related Compounds. LXVI. Reactions of Dialkyl Acylphosphonates with 1,3,4-Thiadiazolium Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
The novel reaction of 1,3,4-thiadiazolium halides (VIIa-c, VIId-e・HBr) with dialkyl acylphosphonates (IIa-b or IIIa-b) in the presence of triethylamine to give 1,3,4-thiadiazine derivatives (VIIIa-e, XIa-d) accompanied by ring expansion was described. In the reaction of VIId-e・HBr with IIa-b or IIIa-b, 10a-(1-dialkylphosphoroyl) benzyl (or ethyl)-10,10a-dihydro-5H-pyrimido [4,5-d]-1,3,4-thiadiazolo [3,2-a]-pyrimidines (Xa-e) were isolated as the intermediates. Neutral hydrolysis of Xa-e gave XIa-d, while alkaline hydrolysis of Xa-e gave tricyclic compounds (XIIa-d). Brief reaction mechanisms are discussed.
- 公益社団法人日本薬学会の論文
- 1970-06-25
著者
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高見沢 映
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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佐藤 久夫
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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佐藤 久夫
塩野義製薬株式会社研究所
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佐藤 久夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi And Co. Ltd.
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
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