Studies on the Pyrimidine Derivatives. XXVII. A New Method for Synthesis of Diethyl Ethoxycarbonylphosphite from Tris (ethoxythiocarbonyl) Phosphorotrithioite, and on the Reactions of these Organo-phosphorus Compounds with Thiamine Sodium Salt.
スポンサーリンク
概要
- 論文の詳細を見る
On the reaction of potassium O-ethyl thiocarbonate (I) or potassium O-ethyl dithiocarbonate (IV) with phosphorus trichloride, tris (ethoxycarbonyl) phosphorotrithioite (IIa) or tris (ethoxythiocarbonyl) phosphorotrithioite (V) were synthesized, respectively. From the treatment of IIa or V with ethyl chloroformate, the same product, diethyl ethoxy-carbonylphosphite (IIIa), accompanied by carbonyl sulfide and ethyl chloride from IIa, and carbon disulfide and ethyl chloride from V, were given in high yield. When tris (alkoxycarbonyl) phosphorotrithioite (II) and thiamine sodium salt (VII) were reacted together, O, S-bis (alkoxycarbonyl) thiamine (IX) was produced. On the other hand, from the reaction of dialkyl ethoxycarbonylphosphite with VII, O, S-bis (ethoxycarbonyl)-thiamine (IXa) was also obtained, but in this cases S-alkylthiamines were main products.
- 社団法人日本薬学会の論文
- 1964-04-25
著者
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佐藤 義朗
Shionogi Research Laboratory Shionogi & Co. Ltd.
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高見沢 映
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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高見沢 映
Niigata College Of Pharmacy
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高見沢 映
Shionogi Research Laboratory Shionogi & Co. Ltd.
関連論文
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- Studies on Pyrimidine Derivatives and Related Compounds. XLVII. Reaction of Thiamine with Dialkyl Acylphos-phonates or Methyl Phenylacyl-phosphinates : Takamizawa Reaction 6
- Studies on Pyrimidine Derivatives and Related Compounds. XLVI. The Reactions of Diethyl Acetylphosphonate with Thiamine : Takamizawa Reaction (5).
- Studies on the Pyrimidine Derivatives and Related Compounds. XL. Reaction of 3-Benzyl-4-methyl-5-(2-hydroxyethyl)thiazolium Salts with Diethyl Benzoylphosphonate
- 41.ピリミジン誘導体および関連化合物の研究(LVI) : ビタミンB_1とリン誘導体との反応(5)(第18回大会研究発表要旨)
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- 14.Pseudoacetothiamineの合成(第162回会議研究発表要旨)
- 101.ピリミジン誘導体および関連化合物の研究(XLIV) : ビタミンB_1および関連化合物とリン誘導体との反応(7)(日本ビタミン学会第17回大会研究発表要旨)
- 100.ピリミジン誘導体および関連化合物の研究(XLIII) : ビタミンB_1および関連化合物とリン誘導体との反応(6)(日本ビタミン学会第17回大会研究発表要旨)
- 99.ピリミジン誘導体および関連化合物の研究(XLII) : ビタミンB_1および関連化合物とリン誘導体との反応(5)(日本ビタミン学会第17回大会研究発表要旨)
- 14.ビタミンB_1関連チアゾール誘導体とDiethylbenzoylphosphonateとの反応(第155回会議研究発表要旨)
- 7.Benzothiamine(VI)(第154回会議研究発表要旨)
- 4.Benzothiamine(V)(第152回会議研究発表要旨)
- 10.ビタミンB_1とリン化合物との反応(IV)(第151回会議研究発表要旨)
- 35.ピリミジン誘導体の研究(XXXVI) : ビタミンB_1-Na塩とDiethyl benzoylphosphonateとの反応(3)(第16回大会研究発表要旨)
- 34.ピリミジン誘導体の研究(XXXV) : ビタミンB_1-Na塩とDiethyl benzoyl phosphonateとの反応(2)(第16回大会研究発表要旨)
- Studies on the Pyrimidine Derivatives. XXVII. A New Method for Synthesis of Diethyl Ethoxycarbonylphosphite from Tris (ethoxythiocarbonyl) Phosphorotrithioite, and on the Reactions of these Organo-phosphorus Compounds with Thiamine Sodium Salt.
- 7.ビタミンB_1新誘導体について(第149回会議研究発表要旨)
- 32.ピリミジン誘導体の合成研究(XXVIII) : カルバモイルサイアミンについて(第14回日本ビタミン学会大会研究発表要旨)
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- Studies on Pyrimidine Derivatives and Related Compounds. LII. Reaction of Thiamine with Phosphites. (1)
- Studies on the Pyrimidine Derivatives and Related Compounds. XXXV. On the Reaction Product of Thiamine with Diethyl Benzoylphosphonate
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- On the Reaction of Dialkyl Acylphosphonate with 2-Methyl-1,3,4-thiadiazolium Salts
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- Studies on Pyrimidine Derivatives and Related Compounds. LXXXVII. Reaction of Thiamine Analogues with Diethyl Benzoylphosphonate
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- Studies on Pyrimidine Derivatives and Related Compounds. LXXII. Syntheses and Reactions of Thiamine Sulfur Analogues and Related Derivatives. (1)
- Studies on Pyrimidine Derivatives and Related Compounds. LXXI. Reaction of Thiamine Anhydride with Thiols
- Studies on Pyrimidine Derivatives and Related Compounds. LXX. A Novel Reaction of Thiamine Anhydride
- Studies on Pyrimidine Derivatives and Related Compounds. LXIX. Sythesis of Thiamine Free Base
- Studies on Pyrimidine Derivatives and Related Compounds. LXVIII. Reactions of Dialkyl Acylphosphonates with 1,3-Disubstituted Benzimidazolium Halides
- Studies on Pyrimidine Derivatives and Related Compounds. LXVII. Reaction of Thiadiazolium Derivatives with Dialkyl Acylphosphonates
- Studies on Pyrimidine Derivatives and Related Compounds. LXVI. Reactions of Dialkyl Acylphosphonates with 1,3,4-Thiadiazolium Derivatives
- Investigation on the Reaction of Benzazolium Salts with Base
- Studies on 2,5-Diaryl-2,4-dihydro-3H-pyrazol-3-ones. II. Synthesis of 4-Cycloalkyl-2,5-diaryl-2,4-dihydro-3H-pyrazol-3-ones Using the Tautomeric Properties of 2,5-Diaryl-2,4-dihydro-3H-pyrazol-3-ones
- Studies on 2,5-Diaryl-2,4-dihydro-3H-pyrazol-3-ones. I. Synthesis of Highly Substituted 1H-Indazoles Using Tautomeric 2,5-Diaryl-2,4-dihydro-3H-pyrazol-3-ones
- Studies on Pyrimidine Derivatives and Related Compounds. LIX. Syntheses of 2,3-Dihydro-1H-pyrazolo [5,1-b] purin-2-ones
- Studies on the Urinary Metabolites of Isophosphamide and Its Activated Species in Rabbits
- Synthesis, Stereochemistry and Antitumor Activity of 4-Hydroperoxyiso-phosphamide (NSC-227114) and Related Compounds
- Syntheses of New Cyclophosphamide Derivatives Having 1,3,4,2-Oxadiazaphosphorinane and Related heterocyclic Systems
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- Studies on Pyrimidine Derivatives and Related Compounds. LXXXI. Reactions of Aryl Isothiocyanates with Thiamine and Related Thiazolium Ylides
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- Studies on Pyrimidine Derivatives and Related Compounds. XLIX. Several Reactions of 1-[(2-Methyl-4-amino-5-pyrimidinyl) methyl]-3-alkyl-4-(2-hydroxyethyl)-5-methyl-imidazolium Salts.
- Studies on Pyrimidine Derivatives and Related Compounds. XLIV. Syntheses of Thiazolo [3,2-a] pyrimidine Derivatives
- Studies on Pyrimidine Derivatives and Their Related Compounds. XCI. On the Oxidation Products of 2-Substituted-1,4-thiazin-3-one Derivatives
- Studies on Pyrimidine Derivatives and Their Related Compounds. LXXXVI. Unusual Reactions of Thiamine Derivatives
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- Studies on Pyrimidine Derivatives and Related Compounds. LXXX. Unusual Reactions of Thiamine Free Base with Electrophilic Reagents. (2)
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- Studies on Pyrimidine Derivatives and Related Compounds. XLV. On Some Synthetic Methods of N-[1-(2-Oxo-1,3-oxathian-4-ylidene) ethyl]-N-[(2-methyl-4-amino-5-pyrimidinyl)-methyl] formamide
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- Studies on Pyrimidine Derivatives and Related Compounds. LXV. On the Reactions of Thiamine with Carbon Disulfide
- Studies on 1,3-Dithiolium Cations. II. Reactions of 4-Phenyl Derivatives with Nucleophilic Reagents
- Studies on 1,3-Dithiolium Cations. I. A Novel Synthetic Method of 4-p-Substituted Phenyl Derivatives and Related Compounds
- Studies on Pyrimidine Derivatives and Related Compounds. LVI. Reaction of Thiamine with Isocyanates. (I)
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- Studies on the Pyrimidine Derivatives and the Related Compounds. XXXVIII. Investigation on 2-Alkoxy-methylene-3-ethoxypropionitrile and Ethyl 2-Alkoxymethylene-3-ethoxypropionate
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- Syntheses of Pyrazole Derivatives. XI. Acetylation Products of 7-Aminopyrazolo [1,5-a] pyrimidines. Supplement
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- Studies on the Pyrimidine Derivatives. XXIV. Syntheses of Several Thiol-type Thiamine Derivatives and their Primary Screening Tests.
- Studies on the Pyrimidine Derivatives. XXII. The Syntheses of New Thiamine Derivatives.
- SYNTHESES OF O, S-DICHOLANOYL-THIAMINE DERIVATIVES
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