Studies on the Synthesis of the Steroids having an Arylcyclopropane Ring at Position 2 and 3. I
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概要
- 論文の詳細を見る
Wolff-Kishner reduction under Huang Minlon's condition of 2-arylmethylene-3-oxo-steroids were investigated, and following results were obtained. 1. Reaction of 2-benzylidene-5α-androstan-3-one (I) gave 2α, 3α-phenylmethylene-5α-androstane (II) and 5α-androstano [3,2-c] pyrazole (IV). 2. Reaction of 2-benzylideneandrost-4-en-3-one (XXII) gave 2α, 3α-phenylmethyleneandrost-4-ene (XXIII), 5β-androstano [3,2-c] pyrazole (XXIV), IV and androst-4-eno [3,2-c] pyrazole (XXV). 3. Reaction of 2-benzylideneandrost-4,6-dien-3-one (XXVI) gave 2α, 3α-phenylmethyleneandrost-4,6-diene (XXVII) and XXV. Stereochemistry of products and reasonable explanation for the reaction process were presented.
- 公益社団法人日本薬学会の論文
- 1969-11-25
著者
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米野 太一郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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林 貞男
Shionogi Research Laboratory Shionogi & Co. Ltd.
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米野 太一郎
Shionogi Research Laboratory Shionogi & Co. Ltd.
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