Bile Acids and Steroids. XVI. Thiosteroisteroids. (5). Ring-opening Reaction of Steroidal 5α, 6α- and 5β, 6β-Epoxide by Thiocy anic Acid.
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概要
- 論文の詳細を見る
Ring-opening of steroidal 5β, 6β-epoxide by thiocyanic acid gave 5α-thiocyanato-6β-hydroxy compound, which was further converted to the 5α, 6α-episulfide via the 5α-thio-cyanato-6β-mesyloxy compound. Reduction of this episulfide with lithium aluminium hydride mainly gave cholesterol and a small amount of 5α-mercapto-3β-ol. Acetylation and saponification reaction of the latter proceeded in a different manner from those of 3β, 5α-diol. Treatment of the 5α, 6α-epoxide with thiocyanic acid or thiolacetic acid gave the 5α-hydroxy-6β-thiocyanato or 5α-hydroxy-6β-acetylthio compound, respectively.
- 公益社団法人日本薬学会の論文
- 1960-08-25
著者
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米野 太一郎
Research Laboratory, Shionogi & Co., Ltd.
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米野 太一郎
Shionogi Research Laboratory Shionogi & Co. Ltd.
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