Thiosteroids. XXII. The Intramolecular Cyclization of 6-Acylthio-, Acyloxy-, and Acylamino-4-en-3-one Steroids. Pentacyclic Steroids
スポンサーリンク
概要
- 論文の詳細を見る
Extension on the cyclization reaction of a steroidal 6α-acetylthio-4-en-3-one by treatment of sodium hydride, giving a methyl thiophene fused at C_4,C_5,and C_6,was studied. Similar cyclization of 6α-acetoxy-and 6α-acetylamino-4-en-3-one, yielding a methylfuro-and a methylpyrrolo compound, respectively, was observed in considerable yield. The more facile cyclization was found in 6α-benzoyloxy-and 6α-benzoylthio-4-en-3-one. The structure of the former, 6-phenylfuro compound, was established chemically by the oxidation to an ene-dione (VI). In addition, benzenosteroids fused at C_4,C_5,and C_6 were also synthesized.
- 公益社団法人日本薬学会の論文
- 1969-12-25
著者
-
米野 太一郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
石原 照一
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
岩倉 彦三
Shionogi Research Laboratory Shionogi & Co. Ltd.
-
井谷 光
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
滝川 喜代子
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
石原 照一
Shionogi Research Laboratory Shionogi & Co. Ltd.
-
滝川 喜代子
Shionogi Research Laboratory Shionogi & Co. Ltd.
-
米野 太一郎
Shionogi Research Laboratory Shionogi & Co. Ltd.
関連論文
- Thiosteroids. XXXVI. Synthesis of Some 16-Sulfur-substituted Steroids
- Thiosteroids. XXI. Episulfide Formation from Vicinal Thiocyanatohydrins and Their Acetates
- Bile Acids and Steroids. XXXIV. Thiosteroids. (19). 6α-and 6β-Thiocyanato-progesterone and Related Compounds.
- Bile Acids and Steroids. XXXII. Thiosteroids. (17). Synthesis of 16β-Acetylthio-and 16β-Alkylthio-estratriene Derivatives
- Bile Acids and Steroids. XXVIII. Thiosteroids. (13). Further Study on Synthesis of 5'-Methylthieno-[4', 3', 2'-4,5,6]-5-en-3-one Steroids
- Bile Acids and Steroids. XXV. Thiosteroids. (10). Synthesis of Some 16β-Acetylthio- and 16β-Alkylthio-estrones and their Derivatives
- Bile Acids and Steroids. XXIII. Thiosteroids. (8). Intramolecular Condensation of Some 6-Acetylthio Steroids.
- Bile Acids and Steroids. XXII. Thiosteroids. (7). Synthesis of Some Thiazolo [5', 4'-16,17] steroids by the Hantzsh Reactions.
- Carbapenem and Penem Antibiotics. VII. Synthesis and Antibacterial Activity of 1β-Methyl-2-(Quaternary Heteroaromatic-thiomethyl) Carbapenems
- Carbapenem and Penem Antibiotics. VI. Synthesis and Antibacterial Activity of 2-Heteroaromatic-thiomethyl and 2-Carbamoyloxymethyl 1-Methylcarbapenems
- Studies on the Synthesis of the Steroids having an Arylcyclopropane Ring at Position 2 and 3. I
- Linear Steroid Analogues. IV. Cyclization Reaction of 8,9-Seco-5α-androstane-8,9,11-trione Derivatives with Al_2O_3 and SiO_2
- Boron Trifluoride-catalyzed D-Homo Rearrangements of 20β-Acetoxy-5α-pregnanes
- 17 ペニシリン-α(R)-スルフォキシドの選択的合成 : ペニシリンからセファロチンへの変換
- Synthesis of 2-Methyl-3-oxa-A-norestra-1,5-(10)-dien-17β-ol and 2-Methyl-3-oxa-4,19-bisnorpregna-1,5(10)-dien-20-one
- Decomposition Reaction of Tosylhydrazones of Steroidal 2α, 5α-Epoxy-3-ketones with Base
- Thiosteroids. XXVI. Steroidal Transannular 2,5-Epoxide and Related Compounds
- Thiosteroids. XXV. Syntheses of the Epimers of Cholest-4-and-5-en-2,3-episulfide and Related Compounds
- Thiosteroids. XXII. The Intramolecular Cyclization of 6-Acylthio-, Acyloxy-, and Acylamino-4-en-3-one Steroids. Pentacyclic Steroids
- Thiosteroids. XXIV. Synthesis of Benzo-c-thieno Steroid : 1-Methyl-3-acetoxy-5'-phenylthieno [4', 3', 2'-4,5,6] estra-1 (10), 2,5,9 (11)-tetraen-17-one
- Thiosteroids. XXIII. Diels Alder Reactions of 5'-Methylfuro-[4', 3', 2', -4,5,6] pregn-5-ene-3,20-dione
- Bile Acids and Steroids. XVII. Thiosteroids. (6). Synthesis of 16β-Mercapto-17α-hydroxyprogesterone and 16β-Mercaptotestosterone
- Bile Acids and Steroids. XVI. Thiosteroisteroids. (5). Ring-opening Reaction of Steroidal 5α, 6α- and 5β, 6β-Epoxide by Thiocy anic Acid.