Carbapenem and Penem Antibiotics. VII. Synthesis and Antibacterial Activity of 1β-Methyl-2-(Quaternary Heteroaromatic-thiomethyl) Carbapenems
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概要
- 論文の詳細を見る
The synthesis and antibacterial activity of a series of 1β-methylcarbapenems having quaternary heteroaromatic-thiomethyl groups at the C-2 position are described. Both 2-hydroxymethyl and 2-chloromethyl carbapenems (1 and 7) respectively served as the common key intermediates for the preparation of these compounds. Of these, the 4-pyridiniothiomethyl derivatives exhibited the best antibacterial properties and turned out to possess high in vivo efficacy as well.
- 公益社団法人日本薬学会の論文
- 1991-03-25
著者
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木村 靖雄
塩野義製薬株式会社新薬研究所
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井谷 光
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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吉田 正
Shionogi Research Laboratories Shionogi & Co. Ltd.
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三和 秀明
Shionogi Research Laboratories Shionogi & Co. Ltd.
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伊牟田 充
Shionogi Research Laboratories Shionogi & Co. Ltd.
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小名 寿男
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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鴻池 敏郎
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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上尾 庄一郎
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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木村 靖雄
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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松浦 真三
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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木村 靖雄
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
鴻池 敏郎
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
上尾 庄一郎
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
井谷 光
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
松浦 真三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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小名 寿男
Shionogi Research Laboratories Shionogi & Co. Ltd.
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