Synthesis and Antibacterial Activity of 1-Substituted-methyl Carbapenems
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概要
- 論文の詳細を見る
The synthesis of the 1α- and the 1β-substituted (fluoro, cyano, hydroxy and acetoxy)-methyl carbapenems having a 2(1,3,4-thiadiazol-2-yl)thiomethyl side chain are described, and their in vitro antibacterial activities are compared with the corresponding 1β-methyl carbapenems together with imipenem. The synthesis and antibacterial activity of the 1β-substituted (fluoro and cyano)-methyl carbapenems having 2-(1-alkyl-4-pyridinio)thiomethyl side chains are also described.
- 公益社団法人日本薬学会の論文
- 1992-09-25
著者
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木村 靖雄
塩野義製薬株式会社新薬研究所
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木村 靖雄
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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木村 靖雄
Shionogi Research Laboratories Shionogi & Co. Ltd.
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元川 清司
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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仙藤 宥二
Shionogi Research Laboratories Shionogi & Co. Ltd.
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紀伊 誠
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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坂ノ上 美喜
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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元川 清司
Shionogi Research Laboratories Shionogi & Co. Ltd.
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紀伊 誠
Shionogi Research Laboratories Shionogi & Co. Ltd.
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坂ノ上 美喜
Shionogi Research Laboratories Shionogi & Co. Ltd.
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