Carbapenem and Penem Antibiotics. I. Total Synthesis and Antibacterial Activity of dl-Asparenomycins A, B and C and Related Carbapenem Antibiotics
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概要
- 論文の詳細を見る
Racemic carbapenem antibiotics having a 1-(hydroxymethyl) ethylidene side-chain at C-6 [dl-asparenomycins A (54), B (37), C (53) and related compounds, 55,56,38,59 and 45] were synthesized starting from the common intermediates 9a and 9b, and their antibacterial activities were examined. The synthesis involves transformation of a cyclic carbonate group into the 1-(hydroxymethyl) ethylidene moiety with a catalytic amount of 1,8-diazabicyclo [5. 4. 0] undec-7-ene (DBU) in an appropriate solvent, and deblocking of the p-methoxybenzyl ester group by the AlCl_3-anisole method.
- 公益社団法人日本薬学会の論文
- 1985-10-25
著者
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吉田 正
Shionogi Research Laboratories Shionogi & Co. Ltd.
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上尾 庄一郎
Shionogi Research Laboratories Shionogi & Co. Ltd.
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元川 清司
Shionogi Research Laboratories Shionogi & Co. Ltd.
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小名 寿男
Shionogi Research Laboratories Shionogi & Co. Ltd.
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元川 清司
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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