Synthesis of 1-Carbacephem Derivatives
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概要
- 論文の詳細を見る
Total syntheses of several types of racemic 1-carbacephem derivatives, 30,32,35,37,39,45,46,50,56,57,58,65,and preliminary biological results are described. Addition of azidoacetyl chloride to the Schiff base 10 in the presence of triethylamine gave cis-azetidinones 11a, b which were converted to the racemic key intermediate 5. By applying sequences of reactions developed in 1-oxacephem syntheses, various kinds of 1-carbacephems were prepared from 5. Among twelve derivatives prepared, 50 showed the highest antibacterial activity.
- 公益社団法人日本薬学会の論文
- 1980-05-25
著者
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上尾 庄一郎
Shionogi Research Laboratories Shionogi & Co. Ltd.
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小名 寿男
Shionogi Research Laboratories Shionogi & Co. Ltd.
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