Carbapenem and Penem Antibiotics. VI. Synthesis and Antibacterial Activity of 2-Heteroaromatic-thiomethyl and 2-Carbamoyloxymethyl 1-Methylcarbapenems
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概要
- 論文の詳細を見る
The synthesis and antibacterial activity of the 1-methylcarbapenems, 2-heteroaromatic-thiomethyl and 2-carbamoyloxymethyl derivatives having a 6-[(R)-1-hydroxyethyl] side chain, are described. The introduction of a methyl substituent at the C-1 position was accomplished by a newly developed procedure using crotyl halides and zinc dust. The 2-hydroxymethyl carbapenems as key intermediates allowed an easy entry into the preparation of title carbapenems.
- 公益社団法人日本薬学会の論文
- 1991-03-25
著者
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井谷 光
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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吉田 正
Shionogi Research Laboratories Shionogi & Co. Ltd.
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伊牟田 充
Shionogi Research Laboratories Shionogi & Co. Ltd.
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小名 寿男
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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上尾 庄一郎
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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上尾 庄一郎
Shionogi Research Laboratories Shionogi & Co. Ltd.
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浜田 芳徳
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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浜田 芳徳
Shionogi Research Laboratories Shionogi & Co. Ltd.
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井谷 光
Shionogi Research Laboratories Shionogi & Co. Ltd.
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小名 寿男
Shionogi Research Laboratories Shionogi & Co. Ltd.
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