Study on the Synthesis of rac-3-Methoxy-6-oxo-N-methylmorphinan

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概要

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• rac-3-Methoxy-6-oxo-N-methylmorphinan was synthesized from 1-(p-methoxybenzyl)-2-methyl-6-oxo-Δ^<9,10>-octahydroisoquinoline and also from 1-(p-methoxybenzyl)-2-methyl-6-oxo-Δ^<5,10>-octahydroisoquinoline by the action of 85% phosphoric acid according to Grewe's cyclization, respectively. 1-(p-Methoxybenzyl)-2-methyl-6,6-ethylenedioxy-Δ^<9,10>-octahydroisoquinoline, which was used as a starting material, was prepared from 2-(p-methoxybenzyl)-2-methyl-6,6-ethylenedioxy-Δ^<9,10>-octahydroisoquinolinium chloride by means of Stevens'rearrangement.

• 公益社団法人日本薬学会の論文
• 1968-05-25

著者

• 前田 量三

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 大杉 栄一

  Shionogi Research Laboratories Shionogi & Co. Ltd.

関連論文

• Synthetic Studies on Diuretics. 5-(3,3-N, S-Substituted-2-propenoyl)-2,3-dihydro-2-benzo[b]furancarboxylic Acids
• Optical Resolution and Chiral Synthesis of Methyl 6,7-Dichloro-2,3-dihydrobenzo[b]furan-2-carboxylate
• Studies on the Synthesis and Analgesic and Anti-inflammatory Activities of 2-Thiazolylamino- and 2-Thiazolyloxyarylacetic Acid Derivatives
• Study on the Synthesis of rac-3-Methoxy-6-oxo-N-methylmorphinan

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