Stereospecific Labeling at α-Position of Phenylalanine and Phenylglycine with Amino Acid Racemase

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概要

• 論文の詳細を見る

• Amino acid recemase with low substrate specificity(EC 5.1.1.10)purified from Pseudomonas putida ATCC17642 catalyzes the racemization of various amino acids but not that of aromatic and acidic amino acids. However, phenylalanine and phenylglycine underwent α-hydrogen exchange with deuterium from the solvent when incubated with the racemase in deuterium oxide. Each enantiomer of both α-deuterated phenylalanine and phenylglycine was produced stereospecifically with retention of the C_2 configuration. This α-hydrogen exchange reaction is applicable to the production of α-deuterated phenylalanine and phenylglycine.

• 社団法人日本生物工学会の論文
• 1998-10-25

著者

• Esaki N

  Institute For Chemical Research Kyoto University

• Esaki Nobuyoshi

  Kyoto Univ.

• Esaki Nobuyoshi

  Nstitute For Chemical Research Kyoto University

• Esaki Nobuyoshi

  京都大学化学研究所 分子微生物科学

• Ezaki Nobuyoshi

  Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University

• Esaki Nobuyoshi

  Institute for Chemical Research, Kyoto University

• YOSHIMURA Tohru

  Institute for Chemical Research, Kyoto University

• Esaki Nobuyoshi

  Inst. For Chemical Res. Kyoto Univ.

• SODA Kenji

  Institute for Chemical Research, Kyoto University

• Soda K

  Kansai Univ. Osaka Jpn

• Soda Kenji

  Department Of Biotechnology Kansai University

• Soda Kenji

  Institute For Chemical Research Kyoto University

• Soda Kenji

  Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University

• Soda Kenji

  Department Of Biotechnology Faculty Of Engineering Kansai University

• Soda Kenji

  Institute For Chemical Resarch Kyoto University

• Lim Young

  Institute For Chemical Research Kyoto University

• Esaki N

  Kyoto Univ.

• Yoshimura Tohru

  Institute For Chemical Research Kyoto University:(present Address)department Of Applied Molecular Bi

• Esaki Nobuyoshi

  Kyoto Univ. Kyoto Jpn

• Esaki Nobuyoshi

  Institute For Chemical Resarch Kyoto University

• LIM YOUNG-HEE

  Institute for Chemical Research, Kyoto University

• Soda K

  Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University

• Soda K

  Department Of Biotechnology Kansai University

• Sato Kumi

  Department Of Bioresources Chemistry Graduate School Of Natural Science And Technology Okayama Unive

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