Enzymatic Synthesis of L-Pipecolic Acid by Δ^1-Piperideine-2-carboxylate Reductase from Pseudomonas putida

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概要

• 論文の詳細を見る

• L-Pipecolic acid is a chiral pharmaceutical intermediate. An enzymatic system for the synthesis of L-pipecolic acid from L-lysine by commercial L-lysine α-oxidase from Trichoderma viride and an extract of recombinant Escherichia coli cells coexpressing Δ1-piperideine-2-carboxylate reductase from Pseudomonas putida and glucose dehydrogenase from Bacillus subtilis is described. A laboratory-scale process provided 27 g/l of L-pipecolic acid in 99.7% e.e.

• 社団法人 日本農芸化学会の論文
• 2007-09-23

著者

• Kurihara Tatsuo

  京都大学化学研究所 分子微生物科学

• Kurihara T

  Laboratory Of Applied Biological Chemistry Department Of Synthetic Chemistry And Biological Chemistr

• Kurihara Tatsuo

  Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University

• Esaki N

  Institute For Chemical Research Kyoto University

• Esaki Nobuyoshi

  Kyoto Univ.

• Esaki Nobuyoshi

  Nstitute For Chemical Research Kyoto University

• Esaki Nobuyoshi

  京都大学化学研究所 分子微生物科学

• Ezaki Nobuyoshi

  Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University

• Kurihara Tatsuo

  Institute for Chemical Research, Kyoto University

• Esaki Nobuyoshi

  Institute for Chemical Research, Kyoto University

• Kurihara T

  Institute For Chemical Research Kyoto University

• MIHARA Hisaaki

  Institute for Chemical Research, Kyoto University

• Esaki Nobuyoshi

  Inst. For Chemical Res. Kyoto Univ.

• Kurihara Tatsuo

  Inst. For Chemical Res. Kyoto Univ.

• Mizuno Haruo

  Departments Of Pediatrics And Neonatology Nagoya City University Graduate School Of Medical Sciences

• Mizuno Haruo

  Department Of Biotechnology Graduate School Of Engineering Osaka University

• Mizutani H

  Dep. Of Biotechnology Coll. Of Life Sciences Ritsumeikan Univ.

• MURAMATSU Hisashi

  Institute for Chemical Research, Kyoto University

• YASUDA Mari

  Yokohama Research Center, Mitsubishi Chemical Corporation

• UEDA Makoto

  Yokohama Research Center, Mitsubishi Chemical Corporation

• Yasuda Mari

  Yokohama Research Center Mitsubishi Chemical Corporation

• Esaki N

  Kyoto Univ.

• Kurihara T

  Kyoto Univ. Kyoto

• Esaki Nobuyoshi

  Kyoto Univ. Kyoto Jpn

• Esaki Nobuyoshi

  Institute For Chemical Resarch Kyoto University

• Mizutani Hisashi

  Department Of Chemistry Faculty Of Science Osaka City University

• Matsubara Hiroshi

  Institute For Chemical Research Kyoto University

• Mizuguchi H

  Department Of Biochemistry Osaka Medical College

• Murai Hiroki

  名古屋市立大学 医学研究科新生児･小児医学分野

• Kurihara Tatsuo

  Institute For Chemical Research Kyoto University

• Murai Hiroki

  Department Of Pediatrics And Neonatology Nagoya City University Graduate School Of Medical Sciences

• Ueda Makoto

  Yokohama Research Center Mitsubishi Chemical Corporation

• Mihara Hisaaki

  Institute For Chemical Research Kyoto University

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