Amino Acid Racemases : Functions and Mechanisms
スポンサーリンク
概要
- 論文の詳細を見る
L-Amino acids are predominant in living organisms, but D-amino acids such as D-alanine and D-glutamate also occur in all eubacterial cell walls. Moreover, even mammals contain endogeneous D-amino acids: D-serine functions as a signaling molecule in mammalian brains, and D-aspartate acts as a mediator in endocrine systems. Various other D-amino acids have been demonstrated in archaea, yeasts, fungi, plants, insects, mollusks and other eucaryotic organisms. These D-amino acids are mostly endogenous and produced in most cases by racemization from their corresponding antipodes by the action of racemases. Therefore, amino acid racemases play a central role in D-amino acid metabolism. Most amino acid racemases require pyridoxal 5'-phosphate (PLP) as a coenzyme, but several others require no coenzymes. Recently, the structures and functions of these two classes of amino acid racemases were clarified on a molecular basis. We here describe recent advances in studies of the functions and mechanisms of PLP-dependent and -independent amino acid racemases.
- 社団法人日本生物工学会の論文
- 2003-08-25
著者
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Esaki N
Institute For Chemical Research Kyoto University
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Esaki Nobuyoshi
Kyoto Univ.
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Esaki Nobuyoshi
Nstitute For Chemical Research Kyoto University
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Esaki Nobuyoshi
京都大学化学研究所 分子微生物科学
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Ezaki Nobuyoshi
Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University
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Esaki Nobuyoshi
Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University
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Esaki N
Kyoto Univ. Kyoto Jpn
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吉村 徹
Institute For Chemical Research Kyoto University
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YOSHIMURA TOHRU
Laboratory of Microbial Biochemistry, Institute for Chemical Research, Kyoto University
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Esaki Nobuyoshi
Inst. For Chemical Res. Kyoto Univ.
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Esaki N
Kyoto Univ.
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Esaki Nobuyoshi
Kyoto Univ. Kyoto Jpn
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Esaki Nobuyoshi
Institute For Chemical Resarch Kyoto University
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Yoshimura Tohru
Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University
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YOSHIMURA Tohru
Laboratory of Biochemistry, Department of Agricultural Chemistry, Kyoto University
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