Changes in Platelet Aggregation and Lipid Metabolism in Rats Given Dietary Lipids Containing Different n-3 Polyunsaturated Fatty Acids
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概要
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We compared the effects of different n-3 polyunsaturated fatty acids (PUFA) on platelet aggregation and lipid metabolism in rats. a-Linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) were used as n-3 PUFA sources. The rats were fed diets containing 10% lipids (polyunsaturated/saturated fatty acid (P/S) ratio=1.0; n-3/n-6=0.02 for the control group, 0.2 for the test groups) for two weeks. The platelet counts, platelet aggregation, and production of thromboxane A2 (TXA2), plasma total cholesterol (TC) and triacylglyc-erols (TG) were not different between the ALA group and the control group, but showed a decreasing tendency for the EPA group and significant decreases for the DHA group. The production of prostacyclin in the aorta was significantly decreased in all of the n-3 PUFA groups when compared with that in the control group. Liver TC and TG concentrations were significantly decreased in the DHA group when compared with those in the control group. Based on the above, it is assumed that the physiological action exerted by n-3 PUFA differs by type and that DHA is a more effective n-3 PUFA, both for suppressing platelet aggregation and for modulating lipid metabolism in the plasma and liver of rats.
- 財団法人 学会誌刊行センターの論文
著者
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和田 政裕
Faculty Of Pharmaceutical Sciences Josai University
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INNAMI Satoshi
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agri
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Yamada Norihiro
Department of Cardiology, Tokyo Women's university
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Shimizu Jun
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
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Yamada Norihito
Department Of Nutrition Faculty Of Agriculture Tokyo University Of Agriculture
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Takita Toshichika
Department Of Nutrition Tokyo University Of Agriculture
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Wada Masahiro
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
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Wada M
The Faculty Of Engineering Tokushima University
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Shimizu J
城西大学
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SHIMIZU Jun
Department of Nutrition, Faculty of Agriculture, Tokyo University of Agriculture
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WADA Masahiro
Department of Agricultural Chemistry, Tokyo University of Agriculture
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