Successful Treatment of an Unresectable Inflammatory Myofibroblastic Tumor of the Frontal Bone Using a Cyclooxygenase-2 Inhibitor and Methotrexate
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概要
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Inflammatory myofibroblastic tumor (IMT) is a disease characterized by tumorous lesions consisting of myofibroblastic spindle cells and inflammatory cells that occur primarily in the soft tissues and viscera of children and young adults. Total excision is the most effective therapy. Steroids have been used to treat unresectable lesions with some success. We herein report a case of IMT involving the frontal bone accompanied by pachymeningitis. The tumor was characterized by an aggressive clinical course that was refractory to prednisolone. Performing total excision seemed difficult. Celecoxib and methotrexate were effective treatments. Our experience suggests the efficacy of celecoxib and methotrexate as alternatives for treating unresectable IMT.
- 社団法人 日本内科学会の論文
著者
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Shimizu Jun
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
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Matsukawa Takashi
Department Of Anesthesia Yamanashi University Medical School
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Tsuji Shoji
Department Of Neurology Brain Research Institute Niigata University
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Shibahara Junji
Department Of Human Pathology The University Of Tokyo
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Tanaka Masaki
Department Of Anatomy & Neurobiology Kyoto Prefectural University Of Medicine
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Kusunoki-Nakamoto Fumiko
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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Miyagawa Toji
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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Yamamoto Tomotaka
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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Ikemura Masako
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan
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