Aqueous Extract of Kotahla Himbutu (Salacia reticulata) Stems Promotes Oxygen Comsumption and Supresses Body Fat Accumulation in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Kothala himbutu (KT) is a traditional medicinal plant used in treating diabetes in Ayurvedic medicine. We investigated the effect of the aqueous extract of KT stems (KTE) on energy expenditure in normal mice. Male C57BL/6J mice (n=28) were divided into 4 groups depending on the type of diet they were fed for 9 weeks: normal (N) diet group (N: 13.8% energy in the form of fat), high-fat (HF) diet group (HF: 53.0% energy in the form of fat), 0.1% freeze-dried KTE (KTED)-supplemented N diet group (N+KTED), and 0.1% KTED-supplemented HF diet group (HF+KTED). KTED intake significantly reduced body weight gain in mice in the N and HF groups. Although it did not affect the plasma levels of glucose, triglyceride, and nonesterified fatty acid, KTED significantly decreased the HF diet-induced increased plasma insulin level. The epididymal and perirenal white adipose tissue (WAT) weights were significantly lower in the HF+KTED group than in the HF group. The oxygen consumption (VO_2), measured by indirect calorimetry, of the mice in the KTED-supplemented groups was significantly higher than that of the mice in the N and HF control groups. Moreover, KTED significantly reduced the size of epididymal WAT adipocytes in the N and HF groups. Thus, KTED promoted VO_2 and suppressed WAT accumulation in the mice on the N and HF diets. Therefore, KTE is beneficial in reducing N diet- and HF diet-induced obesity, which may be partly attributable to the stimulation of whole body energy metabolism.
- 2008-12-01
著者
-
WADA Masahiro
Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai Unive
-
SHIMIZU Jun
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
-
清水 純
城西大学
-
Im Ryanghyok
Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai Univ
-
Mano Hiroshi
Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai Univ
-
Nakatani Sachie
Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai Univ
-
Shimizu Jun
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
-
Im Ryanghyok
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
-
Wada Masahiro
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
-
Mano Hiroshi
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
-
Mano Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo University Of Agriculture
-
Nakatani Sachie
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
-
Mano Hiroshi
Faculty of Pharmaceutical Science, Josai University
-
WADA Masahiro
Department of Agricultural Chemistry, Tokyo University of Agriculture
関連論文
- Aqueous Extract of Kotahla Himbutu (Salacia reticulata) Stems Promotes Oxygen Comsumption and Supresses Body Fat Accumulation in Mice
- Dietary curdlan suppresses dimethylhydrazine-induced aberrant crypt foci formation in Sprague-Dawley rats
- Effect of partially hydrolyzed curdlan on serum and hepatic cholesterol concentrations, and cecal fermentation in rats.
- Dietary Fiber Suppresses Elevations of Uric Acid and Allantoin in Serum and Urine Induced by Dietary RNA and Increases Its Excretion to Feces in Rats
- Dietary Curdlan Increases Proliferation of Bifidobacteria in The Cecum of Rats
- Effect of Cobalamin on the Allergic Response in Mice
- Curdlan and Gellan Gum, Bacterial Gel-Forming Polysaccharides, Exhibit Different Effects on Lipid Metabolism, Cecal Fermentation and Fecal Bile Acid Excretion in Rats
- Secretion and Excretion of Immunoglobulin A to Cecum and Feces Differ with Type of Indigestible Saccharides
- Effect of Indigestible Saccharides on B Lymphocyte Response of Intestinal Mucosa and Cecal Fermentation in Rats
- Changes in Blood Coagulation, Platelet Aggregation, and Lipid Metabolism in Rats Given Lipids Containing Docosahexaenoic Acid
- Accelerating Effect of Chitosan Intake on Urinary Calcium Excretion by Rats
- Effect of Dietary n-3/n-6 Fatty Acid Ratio on the Total Count, Fatty Acid Composition, and Histamine and Leukotriene Concentrations of Mast Cells in Tunica Mucosa Bronchiorum of Type I Allergic Guinea Pig
- The capacity of the natural ligands for CD28 to drive IL-4 expression in naive and antigen-primed CD4^+ and CD8^+ T cells
- Warfarin reduces the incidence of osteonecrosis of the femoral head in spontaneously hypertensive rats
- A clinicopathologic evaluation of renal artery stenosis with abdominal aortic aneurysm
- Spontaneous Regression of an Asymptomatic Meningioma Associated With Discontinuation of Progesterone Agonist Administration
- A new mutation, ataxia and male sterility (ams), of autoimmuneprone MRL/lpr mouse is not linked to lpr gene but associated with reduction of spleen size and alteration of lymphocyte subpopulations
- ICONE11-36525 Macroscopic Streaming Associated with Standing Internal Wave
- Intraductal growth of a nonfunctioning endocrine tumor of the pancreas
- immunologic self-tolerance maintained by CD25^+CD4^+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking theior anergic/suppressive state
- Glucosamine Regulates Differentiation of a Chondrogenic Cell Line, ATDC5(Molecular and Cell Biology)
- Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)
- A 52-year-old man with hypohidrosis
- Safety Evaluation of the Aqueous Extract Kothala Himbutu (Salacia reticulata) Stem in the Hepatic Gene Expression Profile of Normal Mice Using DNA Microarrays
- Signal transduction and transcriptional regulation during mesenchymal cell differentiation
- Antineutrophil Cytoplasmic Antibody (ANCA)-associated Glomerulonephritis with Intrarenal Aneurysms and Renal Arteriovenous Fistulaes
- A34 Research on 3D data Acquisition and Configuration of Live Images(M4 processes and micro-manufacturing for science)
- A33 Research on Chemical Reaction Assisted Ultra-short Pulsed Laser Cleavage-cutting of Silicon Wafer(M4 processes and micro-manufacturing for science)
- A32 Study on Path Control Scheme by Potential Method for Vision Guided Micro Manipulation System(M4 processes and micro-manufacturing for science)
- A28 Research on Enhancement of Photocatalytic Activities of Titanium Dioxide Film Surface by Generating Microcutting Grooves(M4 processes and micro-manufacturing for science)
- Development of Key-Technology on the State-of-the-Art Machine Tool and Generalization of Grinding Forces under Ductile Mode Grinding Experiments
- Analytical Study on Ductile-Regime Scratching of Glasses Using Sharply Pointed Tip Diamond Indenter
- Study on a Diamond Indentation and Scratching of Glasses Using a Micromachining Apparatus
- EFFECT OF A NEW HYPEROSMOTIC AGENT, NIK-242 INJECTION, ON BRAIN WATER CONTENT, METABOLITES AND CEREBRAL BLOOD FLOW IN CEREBRAL ISCHEMIA IN THE SPONTANEOUSLY HYPERTENSIVE RAT
- ROLE OF PLATELETS AS A FACTOR AGGRAVATING CEREBRAL ISCHEMIA
- SUSCEPTIBILITY TO ISCHEMIC INSULT IN HYPERTENSIVE RATS : CORRELATION BETWEEN DEGREE OF ISCHEMIA AND HYPERTENSION
- Is old age a risk factor for dental implants?
- Effects of Various Bone Metabolism-related Factors on a Pure Population of Mature Osteoclasts
- Study of Critical Phenomena by Spin-Cluster Approximation Series:Ising Spin System
- Novel Device for Measuring Vertical Maxillomandibular Registration
- Unilaterally and rapidly progressing white matter lesion and elevated cytokines in a patient with Tay-Sachs disease
- ADENOCARCINOMA IN SITU ARISING FROM THE ECTOPIC SUBMUCOSAL CARDIAC GLANDS OF SHORT-SEGMENT BARRETT'S EPITHELIUM
- CASE OF A MINUTE SESSILE LESION OF THE SIGMOID COLON WITH MASSIVE CANCER INVOLVEMENT IN THE SUBMUCOSAL LAYER
- RARE GASTRIC CALCIFYING FIBROUS PSEUDOTUMOR REMOVED BY ENDOSCOPIC SUBMUCOSAL DISSECTION
- Safety Evaluation of the Aqueous Extract Kothala Himbutu (Salacia reticulata) Stem in the Hepatic Gene Expression Profile of Normal Mice Using DNA Microarrays
- Calculation of Local Environment Effects in Ferromagnetic Transition-Metal Alloys with Atomic Short-Range Order : Method and Application to Fe-V
- Breaking Immunologic Tolerance to Tumor Cells As a Novel Immunotherapy for Cancer
- Identification of a Nuclear Retinoic Acid-binding Activity Representative of Endogeneous Retinoic Acid Receptors in the Nuclei of Rat Liver and Testis
- The role of I-A^ β chain in peptide binding and antigen recognition by T cells
- Research on chemo-mechanical grinding of large quartz glass substrate
- Effects of Dietary n-3/n-6 and Polyunsaturated Fatty Acid/Saturated Fatty Acid Ratios on Platelet Aggregation and Lipid Metabolism in Rats
- Dietary Fiber Suppresses Elevations of Uric Acid and Allantoin in Serum and Urine Induced by Dietary RNA and Increases Its Excretion to Feces in Rats
- Changes in Platelet Aggregation and Lipid Metabolism in Rats Given Dietary Lipids Containing Different n-3 Polyunsaturated Fatty Acids
- Effect of Indigestible Saccharides on B Lymphocyte Response of Intestinal Mucosa and Cecal Fermentation in Rats
- A Theory of Local Environment Effect on the Electronic Structure in Disordered Alloys
- Bacterially Expressed Rat Retinol-binding Protein is Functional for Retinol and Transthyretin Bindings
- Possible Phase Diagrams of Systems with Competing Anisotropies
- Effects of Different Types of Dietary Fiber Preparations Isolated from Bamboo Shoots, Edible Burdock, Apple and Corn on Fecal Steroid Profiles of Rats
- Discrepancy between Spin-Wave Dispersion and Temperature Dependence of Magnetization in Amorphous Ferromagnets
- Novel Device for Measuring Vertical Maxillomandibular Registration
- Inflammatory demyelination in reperfusion nerve injury
- Antineutrophil Cytoplasmic Antibody (ANCA)-associated Glomerulonephritis with Intrarenal Aneurysms and Renal Arteriovenous Fistulaes
- A New Cluster Approximation to the Diluted Ising and Heisenberg Ferromagnets
- Pair-Spin Theory of a Random Mixture with Competing Ising and XY Anisotropies
- Gene Expression of Cellular Retinol-Binding Protein I (CRBP I) is Affected by Dietary Proteins in the Rat Liver
- Culture-negative Brain Abscess with Streptococcus intermedius Infection with Diagnosis Established by Direct Nucleotide Sequence Analysis of the 16S Ribosomal RNA Gene
- Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies
- Oral administration of N-acetyl Glucosamine alters the mRNA expression profile of hyaluronan-related genes in mouse skin
- Role of Second-Neighbor Interaction in Diluted Ferromagnetic Systems
- Effects of Dietary Casein and Soy-Protein on Metabolic Conversion of Eicosapentaenoic Acid to Docosahexaenoic Acid in the Liver of Rat.
- Target-Tracking based on Fusion of Unsynchronized Sensor Data from Vision System and Thermal Imaging Sensor
- Successful Treatment of an Unresectable Inflammatory Myofibroblastic Tumor of the Frontal Bone Using a Cyclooxygenase-2 Inhibitor and Methotrexate
- Evidence for Other Binding Component(s) than Retinoid Receptors Specifically Interacting with a Retinoic Acid Response Element in the Rat Liver.
- Effects of Semi-purified Dietary Fibers Isolated from Lagenaria siceraria, Raphanus sativus and Lentinus edodes on Fecal Steroid Excretions in Rats.
- Effects of Vitamin B12-Deficiency on Testes Tissue in Rats.
- Molecular Dynamics Simulation of Adhesion Effect on Material Removal and Tool Wear in Diamond Grinding of Silicon Wafer
- The phase transition of 1,4-dialkyl-1,4-diazoniabicyclo(2.2.2)octane dibromides, Cn-DABCO-Cn+2-Br.
- Phase transition of unsymmetric bis(quaternary alkyl bromide) salts of 1,4-diazabicyclo(2.2.2)octane, C10-DABCO-Cn-Br2 (11.LEQ.n.LEQ.22).
- A Base-induced Elimination Reaction of Phenylsulfonylacetates. II. Effects of the Base and the Solvent on the Stereochemistry of Elimination
- Target-Tracking based on Fusion of Unsynchronized Sensor Data from Vision System and Thermal Imaging Sensor
- A combination impression technique by Accu-Dent® System broadly extends the surface area of primary casts