EFFECT OF A NEW HYPEROSMOTIC AGENT, NIK-242 INJECTION, ON BRAIN WATER CONTENT, METABOLITES AND CEREBRAL BLOOD FLOW IN CEREBRAL ISCHEMIA IN THE SPONTANEOUSLY HYPERTENSIVE RAT
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概要
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We examined the effects of a new hyperosmotic agent (NIK-242inj.) on brain edema, energy metabolites and regional cerebral blood flow (r-CBF) during acute cerebral ischemia. Cerebral ischemia was induced by bilateral common carotid artery ligation (BLCL) using spontaneously hypertensive rats (SHR). The experimental animals were divided into 4 groups. A:20% NIK-242inj., B:20% mannitol, C:10% glycerol in 5% fructose. D:normal saline. All the animals were administered the agent or saline intravenously beginning at 1h after BLCL and continuing for 2h for a total dose of 6.8ml/kg body weight. Brain water content and metabolites (ATP, lactate. pyruvate) were determined 3h after BLCL. Regional cerebral blood flow (r-CBF) in thalamus was also measured by the hydrogen clearance technique. The brain water content in the NIK-242inj. group was significantly lower than that of saline group. The concentration of brain ATP in the NIK-242inj. group remained higher than those of saline group. Accumulation of lactate in the NIK-242inj. group was less than in the mannitol and saline groups. The lactate/pyruvate ratio of the NIK-242inj. group was significantly lower than that of the saline and mannitol groups. At 3h after BLCL. the reduction of r-CBF in the NIK-242inj. group was smaller than that of saline group. The present study suggests that NIK-242inj. as well as glycerol could ameliorate brain edema, disruption of brain energy metabolism and reduction of r-CBF in acutely induced cerebral ischemia.
- 社団法人日本循環器学会の論文
- 1991-12-20
著者
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清水 純
城西大学
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Katayama Yasuo
日本医科大学 第2内科
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Shimizu J
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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Terashi Akiro
The 2nd Department Of Internal Medicine Nippon Medical School
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KASHIWAGI FUMIHIKO
The Second Department of Internal Medicine, Nippon Medical School
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Shimizu Jun
The 2nd Department Of Internal Medicine Nippon Medical School
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Shimizu J
城西大学
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KASHIWAGI FUMIHIKO
The 2nd Department of Internal Medicine, Nippon Medical School
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KATAYAMA YASUO
The 2nd Department of Internal Medicine, Nippon Medical School
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KAMIYA TATSUSHI
The 2nd Department of Internal Medicine, Nippon Medical School
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Kamiya Tatsushi
The 2nd Department Of Internal Medicine Nippon Medical School
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Kashiwagi Fumihiko
The Second Department Of Internal Medicine Nippon Medical School
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