Dietary Fiber Suppresses Elevations of Uric Acid and Allantoin in Serum and Urine Induced by Dietary RNA and Increases Its Excretion to Feces in Rats
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概要
- 論文の詳細を見る
This study was performed to examine the effects of several kinds of dietary fibers (DF) with different physical properties on dietary RNA metabolism. Male Wistar strain rats, 4 wk old, were fed diets with or without a 3% yeast RNA and a 5% DF (cellulose, chitin, chitosan, inulin, and xanthan gum) for 20 d (Experiment 1) or 5 d (Experiment 2). Feeding DF tested lowered the serum uric acid and allantoin concentrations and the urinary excretions of their compounds and increased the amount of RNA excreted into the feces compared with fiber-free. The water-holding capacity and nucleotide adsorption of chitin and chitosan in acidic solutions were higher than those of cellulose. The digestion rate of RNA by RNase A in vitro was found to be lower in the DF tested than in fiber-free. The decrease was remarkable in chitosan and xanthan gum. The uptakes of 14C-labeled adenosine and adenosine 5-monophosphate (5-AMP) in the rat jejunum were markedly decreased in regard to chitosan and xanthan gum in comparison with the fiber-free. These phenomena suggest that DF with high viscosity is more strongly associated with the suppression of RNA digestion by RNase A and the depression of the uptake of purine compounds to jejunum. The present results reveal that the elevation of serum uric acid concentration induced by dietary RNA can be suppressed by DF in rats.
- 財団法人 学会誌刊行センターの論文
- 2002-06-01
著者
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和田 政裕
Faculty Of Pharmaceutical Sciences Josai University
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INNAMI Satoshi
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agri
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MAEKAWA Akio
Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agri
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Nakajima Hisao
Department Of Human Ecology Toyoko Women's Junior College
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Innami S
Tokyo Univ. Agriculture Tokyo Jpn
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Innami Satoshi
Department Of Nutrition Tokyo University Of Agriculture
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Ikegami Sachie
Division Of Food Science The National Institute Of Health And Nutrition
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Maekawa A
Faculty Of Applied Bioscience Tokyo University Of Agriculture
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Maekawa Akio
Laboratory Of Nutritional Biochemistry Department Of Applied Biology And Chemistry Faculty Of Applie
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Tobimatsu T
Faculty Of Engineering Okayama University
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Toraya Tetsuo
Faculty Of Engineering Okayama University
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Wada Masahiro
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer
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Wada M
The Faculty Of Engineering Tokushima University
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Yamamoto Yuji
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Tadokoro Tadahiro
Department Of Applied Biology And Chemistry Tokyo University Of Agriculture
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Koguchi Takashi
Department Of Applied Biology And Chemistry Faculty Of Applied Bioscience Tokyo University Of Agricu
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Yamamoto Yuji
Laboratory Of Nutritional Biochemistry Department Of Applied Biology And Chemistry Faculty Of Applied Bioscience Tokyo University Of Agriculture
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Yamamoto Yuji
Department Of Applied Biology And Chemistry Tokyo University Of Agriculture
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TADOKORO Tadahiro
Department of Agricultural Chemistry, Tokyo University of Agriculture
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MAEKAWA Akio
Department of Agricultural Chemistry, Tokyo University of Agriculture
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YAMAMOTO Yuji
Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University of Agriculture
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WADA Masahiro
Department of Agricultural Chemistry, Tokyo University of Agriculture
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