Comparison between the Effect of Collagen Tripeptide and Sodium Hyaluronan to Prevent Knee Osteoarthritis : A Preliminary in vivo Study

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　Objective Collagen peptides have recently been shown to have several biological activities, and havebeen used as preservatives and immunotherapeutic agents. The purpose of this study was to investigate the abilityof weekly intra-articular injections of collagen tripeptide （Ctp） to prevent knee osteoarthritis （OA） compared withsodium hyaluronan（ HA）.Methods Thirty rabbits with anterior cruciate ligament（ ACL） transection were randomly divided into three groups:Ctp, HA, and saline（ control）. All animals were administered the same amount of each reagent once weekly. Articularcartilages of the medial condyle of femur were examined by gross morphological and histopathological examinationconducted at 5（ n=6） and 10（ n=4） weeks.Results The Ctp and HA injection groups tended to have improved gross morphological scores and exhibitedpreventive effects compared with control groups at 10 weeks after ACL transection. But the scores were notsignificantly different among the 3 groups. The overall means of histological grading scores were not significantlydifferent among the 3 groups however, the score for the Ctp group had improved from 5 weeks to 10 weeks.Conclusions Intra-articular injections of Ctp may inhibit progression of knee OA, and further examination is neededto clarify the physical characteristics and regenerative functions of Ctp, and to determine the optimal dose andduration of Ctp injection therapy for the knee OA.