Culture-negative Brain Abscess with Streptococcus intermedius Infection with Diagnosis Established by Direct Nucleotide Sequence Analysis of the 16S Ribosomal RNA Gene

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概要

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• A 70-year-old woman developed a headache for a month followed by right upper limb weakness. CT scan and MRI showed multiple ring-enhancing lesions. An intracerebral aspiration of an abscess was performed, but culture results were negative. The nucleotide sequence analysis of the 16S rRNA gene from the specimens identified Streptococcus intermedius. Given this result, S. intermedius was cultured by enrichment culture, and its sensitivities to antibiotics were determined. The patient exhibited complete remission. Thus, 16S rRNA gene analysis was highly useful not only for pathogen identification with negative culture results but also for the appropriate selection of antibiotics.

著者

• Hida Ayumi

  Department Of Clinical Studies Radiation Effects Research Foundation

• Shimizu Jun

  Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Sciences Josai Univer

• Saito Naoko

  Department Of Cardiology Fukuoka University School Of Medicine

• Tsuji Shoji

  Department Of Neurology Brain Research Institute Niigata University

• Ichikawa Yaeko

  Department Of Neurology Graduate School Of Medicine University Of Tokyo

• Hayashi Tetsuya

  Division Of Bioenvironmental Science Frontier Science Research Center University Of Miyazaki

• Hatakeyama Shuji

  Department Of Internal Medicine Showa General Hospital

• Ooka Tadasuke

  Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Japan

• Koide Yuri

  Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan

• Mukasa Akitake

  Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Japan

• Nakatomi Hirofumi

  Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Japan

• Saito Naoko

  Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan

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