Novel Application of Shochu Distillery By-products to Prophylaxis against Mammary Carcinogenesis Induced by 7,12-Dimethylbenz[α]anthracene in Rats
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概要
- 論文の詳細を見る
The effect of the heat-dried product of Shochu distillery by-products (HSDB) derived from sweet potato on mammary carcinogenesis in rats was investigated. HSDB was fed at 2.5% or 5% of the total feed weight. Dietary HSDB at the 5% level suppressed the incidence and number of tumors, and delayed the latency of mammary tumor development relative to the control diet. Experiments were conducted to determine the relative polarity of the anticarcinogenic constituent(s). The number of tumors per tumor-bearing rat was lower in the diet group fed with an ethyl acetate extract of HSDB than in the control group. The tumor incidence evaluated at both palpation and autopsy was slightly lower in the group fed with a methanol extract than in the control group. These results suggest that HSDB contained at least two constituents of differing polarity that counteracted mammary carcinogenesis.
- 2005-10-23
著者
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Abe Makoto
Department Of Internal Medicine Ii University Of Yamanashi
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Sasaki Taku
Department Of Life Sciences Graduate School Of Arts And Sciences The University Of Tokyo
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Sasaki Taku
Department Of Nutritional Science Faculty Of Applied Biological Science Tokyo University Of Agricult
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Takita Toshichika
Department Of Nutrition Tokyo University Of Agriculture
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Takita Toshichika
Department Of Nutritional Science Faculty Of Applied Biological Science Tokyo University Of Agricult
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Abe Makoto
Department Of Nutritional Science Faculty Of Applied Biological Science Tokyo University Of Agricult
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Nakayama Shin'ichi
Department Of Nutritional Science Faculty Of Applied Biological Science Tokyo University Of Agricult
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MORIYAMA Kazuyuki
Kirishima Shuzou Co., Ltd.
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TAHARA Hidetaka
Kirishima Shuzou Co., Ltd.
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Tahara Hidetaka
Kirishima Shuzou Co. Ltd.
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Moriyama Kazuyuki
Kirishima Shuzou Co. Ltd.
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Abe Makoto
Department Of Breast Oncology Cancer Institute Hospital
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ABE Makoto
Department of Biological Production, Akita Prefectural University
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ABE Makoto
Department of Agricultural Chemistry, The University of Tokyo
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