Streptococcus faecalisにおけるピルビン酸酸化とそれに関連する代謝系に関する研究-1-プロピオン酸による増殖阻害機構

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Studies were made on the growth inhibitory effect of propionate on Streptococcus faecalis 10 C 1. The results obtained are as follows; (1) propionate inhibited the aerobic oxidation of pyruvate depending on lipoate in a cell-suspension; (2) pyruvate oxidation using neotetorazolium chloride as a hydrogen acceptor in a cell-free system also required lipoate and was remarkably inhibited by the addition of propionyl phosphate; (3) propionate was converted to propionyl-CoA via the phosphate ester; (4) acetate, being activated in the same cell-free extract, inhibited the activation of propionate. The results suggest that (1) an excess amount of propionate added to the growth medium blocks the acetyl-CoA formation from pyruvate and consequently inhibits the bacterial growth; (2) the well-known effect of lipoate or acetate which eliminates the inhibition may be due to the stimulation of the acetyl-CoA formation.
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