Potential Bile Acid Metabolites. XI. : Syntheses of Stereoisomeric 7,12-Dihydroxy-5α-cholanic Acids
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概要
- 論文の詳細を見る
Three new compounds, 7α, 12β-, 7β, 12α-, and 7β, 12β-dihydroxy-5α-cholanic acids, were synthesized. The principal reactions employed were 1) selective acylation at C-7 of a 7α, 12α-dihydroxy ester with the propionic anhydride-4-dimethylaminopyridine system, 2) potassium superoxide-18-crown-6 ether inversion of the 7α-hydroxyl group, and 3) stereoselective reduction of the 12-ketones with the sodium borohydride-palladium chloride system and tert-butylamineborane complex. High-performance liquid chromatography was of key importance in characterizing the compounds and determining their purity
- 公益社団法人日本薬学会の論文
- 1986-05-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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飯田 隆
College Of Engineering Nihon University
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南原 利夫
Pharmaceutical Institute Tohoku University
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Chang F
Department Of Chemistry Harvey Mudd College
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CHANG Frederic
Department of Chemistry, Harvey Mudd College
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百瀬 利明
College of Engineering, Nihon University
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百瀬 利明
College Of Engineering Nihon University
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CHANG Frederic
Department of Biochemistry, College of Medicine, University of South Alabama
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