Potential Bile Acid Metabolites. X. : Syntheses of Stereoisomeric 3,7-Dihydroxy-5α-cholanic Acids
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概要
- 論文の詳細を見る
New synthetic routes to allochenodeoxycholic (3α, 7α-dihydroxy-5α-cholanic) and alloursodeoxycholic (3α, 7β-dihydroxy-5α-cholanic) acids, and their stereoisomers are described. Treatments of allo 7α-hydroxy-3β-tosyloxy ester with N, N-dimethylformamide and of allo 7α-mesyloxy-3β-tosyloxy and 3β-cathyloxy-7α-mesyloxy esters with potassium superoxide-crown ether afforded the desired 3α, 7α-, 3α, 7β-, and 3β, 7β-dihydroxy stereoisomers, respectively, in high yield. High-performance liquid chromatography was of key importance in characterizing the compounds and determining their purity.
- 公益社団法人日本薬学会の論文
- 1986-05-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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飯田 隆
College Of Engineering Nihon University
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南原 利夫
Pharmaceutical Institute Tohoku University
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Chang F
Department Of Chemistry Harvey Mudd College
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CHANG Frederic
Department of Chemistry, Harvey Mudd College
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百瀬 利明
College of Engineering, Nihon University
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百瀬 利明
College Of Engineering Nihon University
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CHANG Frederic
Department of Biochemistry, College of Medicine, University of South Alabama
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