Stereospecific Hydrogen Addition at C-4 in Transformation of 4-Androstene-3,17-dione into 5α-Androstane-3,17-dione by Penicillium decumbens
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概要
- 論文の詳細を見る
The stereochemistry of the hydrogen addition at C-4 in the microbial 5α-hydrogenation of a ⊿^4-3-ketosteroid has been investigated. 4-d_1-4-Androstene-3,17-dione was converted by incubation with Penicillium decumbens into 5α-androstane-3,17-dione. The position of deuterium retained in the product was elucidated to be 4α by ^1H nuclear magnetic resonance spectroscopy using the lanthanide shift reagent. These results led to the conclusion that the hydrogen addition at C-4 occurs stereospecifically from the β-side in this biotransformation.
- 公益社団法人日本薬学会の論文
- 1977-12-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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石田 秀樹
Pharmaceutical Institute Tohoku University
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細田 宏
Pharmaceutical Institute Tohoku University
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池川 繁男
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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