Synthesis of 15α-Hydroxytestosterone and Related C_<19> Steroids
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概要
- 論文の詳細を見る
The preparation of 15α-hydroxytestosterone (5) and 15α-hydroxyandrostenedione (11) was carried out employing 17β-tert-butyldimethylsilyloxy-6β-methoxy-3α, 5-cyclo-5α-androstan-15α-ol (1) as a key intermediate. In a similar fashion the 15α-hydroxylated 5α-androstane derivatives (20,22,26) were also synthesized. The utilization of tertbutyldimethylsilylation for protecting the hydroxyl group in the preparation of the desired compounds has been demonstrated.
- 公益社団法人日本薬学会の論文
- 1977-10-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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山下 幸和
Pharmaceutical Institute Tohoku University
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山下 幸和
日本化薬(株)医薬事業本部総合研究所
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細田 宏
Pharmaceutical Institute Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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但野 恭一
Pharmaceutical Institute Tohoku University
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