Syntheses of 15α-Hydroxyestrone and 15α-Hydroxyestradiol
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概要
- 論文の詳細を見る
The titled compounds (1,2) have been prepared from estrone by the new synthetic routes. Introduction of a hydroxyl group into the 15α-position was readily attained by hydroboration of the 14,15-or 15,16-double bond with diborane and subsequent oxidation of the organoborane with alkaline hydrogen peroxide. In the preparation of 1 the dimethyl-tert-butylsilyl function was conveniently employed for the purpose of protecting the 3,17β-hydroxyl groups.
- 公益社団法人日本薬学会の論文
- 1975-12-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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山下 幸和
Pharmaceutical Institute Tohoku University
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山下 幸和
日本化薬(株)医薬事業本部総合研究所
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細田 宏
Pharmaceutical Institute Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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