The Synthesis and Conformational Analysis of α-Bromo-16-ketones of 13α-Androstanes
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概要
- 論文の詳細を見る
15α- and 17α-bromo-3β-hydroxy-5α, 13α-androstan-16-one acetates (VI, VII) were synthesized starting from the parent 16-oxosteroid (Ib) by way of the enol acetate (V). Configuration of both bromine atoms introduced was established to be α by the standard method of Fieser and Ettorre. These two positional isomers were readily distinguished by leading to the Δ^<15-> and Δ^<16>-unsaturated compounds (X, XI), respectively. On the basis of infrared, ultraviolet, rotatory dispersion and circular dichroism spectral data, the nature of 15α- and 17α-bonds and the conformation of rign D with a ketone at C-16 were discussed.
- 公益社団法人日本薬学会の論文
- 1969-02-25
著者
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細田 宏
Pharmaceutical Institute Tohoku University
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碓氷 昌宏
Pharmaceutical Institute, Tohoku University
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南原 利夫
Pharmaceutical Institute Tohoku University
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碓氷 昌宏
Pharmaceutical Institute Tohoku University
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