The Synthesis and Conformational Analysis of Epimeric 16-Bromo-5α, 13α-androstan-17-ones
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概要
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Epimeric 3β-acetoxy-16-bromo-5α, 13α-androstan-17-ones were synthesized starting from 3β-acetoxy-5α, 13α-androstan-17-one, and their structures were confirmed by the standard method of Fieser and Ettorre. An equilibrated mixture obtained from each one of epimers with hydrogen bromide was found to consist of 23% 16β and 77% 16α. On the basis of infrared, ultraviolet, nuclear magnetic resonance spectra and optical rotatory dispersion curves the conformation of ring D was discussed.
- 公益社団法人日本薬学会の論文
- 1968-07-25
著者
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南原 利夫
Pharmaceutical Institute, Tohoku University
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合屋 周次郎
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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細田 宏
Pharmaceutical Institute Tohoku University
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合屋 周次郎
Pharmaceutical Institute Tohoku University
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合屋 周次郎
Pharmaceutical Institute Medical Faculty University Of Kyushu
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南原 利夫
Pharmaceutical Institute Tohoku University
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