イオノフォアの静脈内投与が去勢牛の代謝に及ぼす影響

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The effects of i. v. administration of monensin (MN), salinomycin (SL) and lasalocid (LA) on metabolism independent of the rumen were examined using four Holstein steers weighing 266kg in average. Twenty milligrams of sodium salts of each ionophore were dissolved in 2ml ethanol, and injected into the jugular vein at 9:30h, i. e. 1h after the morning feeding. Four animals were assigned to four treatments including the injection of vehicle (2ml ethanol) in a 4×4 Latin square design on every other day. Jugular blood were taken from -15 to 240min after the administration, and the concentration of glucose, non-esterified fatty acids (NEFA), insulin and minerals were measured. The administration of MN caused a rapid increase in plasma glucose and serum NEFA. Concentrations of insulin tended to decrease up to 120min after the administration of MN, and then increased remarkably. Plasma inorganic P, K and Mg levels tended to decrease following the MN injection, whereas plasma Na and Ca levels were not affected throughout the study. The MN induced metabolic disturbances such as polyuria, weeping and muscle tremors for a few hours after the administration. Also the administration of SL tended to increase the concentrations of NEFA and glucose in blood, but the extent of these changes was much less than that by MN. Neither the changes in blood levels of insulin and minerals nor any clinical signs were observed in steers administered SL. The administration of LA hardly affected not only the concentration of any blood constituent but also physical conditions.
社団法人日本畜産学会の論文

イオノフォアの静脈内投与が去勢牛の代謝に及ぼす影響

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