漢方・生薬製剤中のsennoside A, sennoside B, rhein及びrhein 8-glucosideの定量法と修治大黄の成分比較

概要

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By combination of anion-exchange solid phase extraction and HPLC, sennoside A (SA), sennoside B (SB), rhein (RH) and rhein 8-glucoside (RG) in senna and rhubarb, or preparations containing these crude drugs were simultaneously determined. The HPLC system used an ODS column and a mobile phase of acetonitrile-water-acetic acid. The analytical results showed that the RG content was low in senna leaves and high in rhubarbs (5.4-19.3 mg/g rhubarb) and that the SA and SB contents were quite low in some Kampo preparations on the market: sometimes they were too low to be detected. In the processed rhubarbs, shu-daio (酒大黄), juku-daio (熟大黄) and daio-tan (大黄炭) experimentally prepared in our laboratory, the laxative components, SA and SB, were not detected in juku-daio and daio-tan, but RH was detected in all the three processed rhubarbs.
日本生薬学会の論文
1996-04-20