改質したγ-リノレン酸高含有ボラージ油とα-リノレン酸高含有亜麻仁油が自己免疫疾患易発症マウスMRL/lprに及ぼす影響

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Effects of omega 3 and omega 6 unsaturated fatty acids on the autoimmune factors in MRL/lpr prone mice were investigated. Linseed oil was used as alpha-linolenic acid-rich oil (about 56%). Gamma-linolenic acid-rich oil containing the same amount as alpha-linolenic acid in linseed oil was prepared from borage oil. These oils and soybean oil were fed to the mice from 8 weeks old to 20 weeks old. Body weight of gamma-linolenic acid-rich oil group was significantly lower than that of alpha linolenic acid-rich oil group. Spleen swelling was suppressed by the administration of alpha and gamma-linolenic acids-rich oils, compared with soybean oil group. The suppression of the production of autoantibody and the decrease in urine albumin concentration were also observed. The administration of alpha-linolenic acid reduced the production of TNF-alpha, IL-1beta, and IL-6. Gamma-linolenic acid group gave the intermediate score. The production of IL-18 showed the highest value in soybean oil group.
2006-12-30